VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Caenorhabditis elegans

Scientific Name: Caenorhabditis elegans

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Protostomia-> Ecdysozoa-> Nematoda-> Chromadorea-> Rhabditida-> Rhabditina-> Rhabditomorpha-> Rhabditoidea-> Rhabditidae-> Peloderinae-> Caenorhabditis

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Human coronavirus NL63

Family: Coronaviridae

Receptor: ACE2

Receptor ACE2 information

Summary: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_1010 2016.08 Nextera XT Embryo Normal 218 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of ACE2 in human tissues   [NCBI]

Expression: Biased expression in small intestine (RPKM 93.7), duodenum (RPKM 69.0) and 5 other tissues

Protein expression of ACE2 in human tissues   [Proteinatlas]